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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '081e21886ea779bc6c11e4a3bb8d3d47d5b56737caaa3a256cc470bfaba1213f' 
  AND token = 'HbIZxFZ12Tmd7fzkka3Ohq5cupeFcV4aU9Wm2ke6Loc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}