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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c022dd933b535c85bc41654a906d139b2c8f51f1e630074c042782f821820b4a' 
  AND token = 'S1VVa07nnF1wzoTftmlkHdRvaV4dLbFQ3CYSGQ3Ddg0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}