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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49e050caa5c5855294b5378a176a0566863c28d19bf6daef91c9927135e33c9d' 
  AND token = '0dMI65yXk2sJh2dpBUf4XHNVRL9u3UGeRcc/uC7xpYE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}