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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '41d49639a475a6b0618581250396141ae6cb297704ecc4bf3c92d2695f3f7568' 
  AND token = 'wlx9XeR3IWWvac0H3++9aaaspA+ZuVYzfc0v1ZBnuF8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}