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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7161c14e5ec91218a2f397c7f9ccdb563ac07c070eac166c2bc3c4f484b8f843' 
  AND token = 'EEXnMMgojUCPk6DHCU+K6X+RaRAiux5YLI9cU3Jvj5s=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}