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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '25e60ec12776177d0b6ae99ed7555f07d71c6f311aaaf7e8da425876dc48b37b' 
  AND token = '2EoMvl3Ck+WJeR2+hVOMV5F9eRHnc4booj5ce8SdZ/4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}