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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0b4196fdd8d48e19f4f70ef99dd0b2bd7eeda3fa37eaa82c38404d164683a742' 
  AND token = 'R7pMVHX+n1f/7mrcVcT3GbM0tDpo8lv6zRfFAGdRPEY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}