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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2c72a1cf3845c9f6d6e69d3edd200f988be84a89ae1a4274a13914e3f3e9dec5' 
  AND token = '7Sc+uv0iBm11ZyPm4zIvfBojeDWLVap1l5S/WpWf2mw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}