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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ff6dfb5a804d28e6d9deda3a5b6dd7e8b4864215aaea8429e327448c1b22f697' 
  AND token = 'DQJQeOGjIuI0dwgmVVVQoUylG9ozxTqcMLkyxrSd8Vo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}