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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b2105b8811af17c4cd0f04756cf04a579db308ecf678d71ed4463f5a76d2cbc4' 
  AND token = 'oOkaR+0XrjjpouoauCTofuesHKRZ+o7MSPtOHlWMoLU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}