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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '257e6d09a63230fb7ac116ab0893b88d88f69d7788aef46a91221f44f074876c' 
  AND token = 'Zu340A3ge4mRFPiWwn8HZrYWrDR5bYib1H/De4C1tcc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}