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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b88d543c59a97ff516c987cb7ecab13cc3591d228d2b575a52fda35d2f14cbc6' 
  AND token = 'O7UStcarDRNRZF9ElUaqoQ/YG1DD4yUpyzUyM+DBZRM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}