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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '48e36b6a41829c0cece2189737343ff082eaea6b75525711a7efafe89a83a6a0' 
  AND token = 'Sy253DKIoxK6qFiFJnE+brI+fDxHNwUuCrQESPrHFkg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}