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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4dfe60f1504b83f4b59cadc241df5bbf5687b3ffeafb5e9df3b3b911452c76b7' 
  AND token = 'JBSi0ka3du0nPJaNZckfwDy1w0u1DoCY0VK01H6xekE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}