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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '14e181a67e44f0e33738031809c03bf82210a57eb7046766b067cfd5edf7a720' 
  AND token = '4U4mmAFOU0vUj/hOs3TzSYKwTApx14uCkSkGbo1aQpQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00016

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}