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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8cada1d16bdf6d32c45228d8c8fa1a3ed40515ba0ee4bfd6b1102a0989693ff2' 
  AND token = '+9w8+SWAIQ0ixtSld1abNETrZ6DzSy16x3wRkaMd+RA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}