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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '758a1340e38bb35c0e0d7ca822a3fa728f34f9ff8749965846608d5b50d3bebb' 
  AND token = 'qAy4W2YZ8GEK3xIrTALUERLm0IMJS+UXRNJZzsxv3N8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}