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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '437904308c383f11cb9102c95eb2e6216701a1fe58385d2c7ee65101f4327ef3' 
  AND token = '84q/UCaiWgoCCokaoazchpFHsXRvV03I2HABBIBcAww=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}