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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7378824ad6b50da4b51adfaf1436e193fae71e265764480bb0f4b6e74414ab32' 
  AND token = 'ZAac2UfJp2vGcSOnccJL8j8tFlmVKbzAV5mu+Gi6EKo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}