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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49d5e3206ac655b51e435933f25ed5075ec240e538a4f70c555cb078f27b810c' 
  AND token = 'samjT6w/e31CAAIGAyAUD5f30URQgJfgwAg3FZMMlHA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}