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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4b0645ac130c3e0d69dad8f7882162c627fb394ca9e1227015d7e82f3aa0624e' 
  AND token = 'qpWU0Y/99lhQlWERcA+FhN2nhkEWyc7pw98WvsLnHXM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}