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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '016f53afb44bdd0caf6b8fb6b63e06fb9d8ab54cc180c38c5a436178cd4d3d81' 
  AND token = 'KhOd1X8X1LstoYSo4R1eycB2rmcXXErEkb+7QaFQ1Xo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}