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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4e439fbc40aba36fcda17e0ba64e21d42ab407f6e85e2e087f71a9d44bae2993' 
  AND token = 'mDGVqSjwZGdC4cgD2hMos8nEcJr4AeuMwLiOfTAIoHM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}