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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0f4d2cfd66bf6619b813df5cef2620ccefca5751aa997f1c48c074164b6e12a7' 
  AND token = 'Y9RW7Y4rrETC+vEoofD0VJFqWS1kx8N8jDyEyyf5GTs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}