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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1446392ada183c9fb4fbb645433e0f1f5eb0d0bb66a1244077b2a36100afd2bc' 
  AND token = 'mXa8LJ7uxSfFtMykeVBDqDGaSiZEJCXe9vzM765w7zU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}