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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21ef346c695c50c56d10d9568a9eb50f0946f3b6db9634414f101d0251402dcd' 
  AND token = 'f7XAo6IPOJt+2vFxsenpBjKjiw4Uo3xRlQf9R7kBwb0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}