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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '224b8e1638d6a298b3e94ec1fbad7e846e92ad90c255559e4cbf7ff25e16dab2' 
  AND token = 'caEmPUrI5RTx5aRFERjNo1exT0RUD68ErdJA03qgZ00=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}