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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4b4d1700abb542444d6881691f32c1d87d284d1eda070db43b79ac7afe678dd4' 
  AND token = 'E5sURjSWzCJtyw/HaWH4xLnAaigNtLBVoKuYvx9jpTA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}