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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '645cbb7cc64cb9c2862e218c64d2f6787013be1960a2250e3fa46c85cdc38b78' 
  AND token = 'WM+SZTKxibWEhl+EHi8vnN7VnPO7gNXocTcI1bVJRMQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}