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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4da46408a921622fee2411fb3a00b4e4aa0e73e05016c96345b059a32ba59b08' 
  AND token = '/B3KuTAE+M47mbvSqpvraU8GOB+pDjbqorJI+mo0Vzs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}