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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '417cc2b3581844d8804d93c2a30d71456248f1622bbc1cceb1923c3a8943e11a' 
  AND token = 'xeyQuTzQTiqyivsWBj/xli7TkYlPlVTR2u3b8jiwW4I=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}