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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6d4a8edf6bf8e28cb143267e64713be29259d07115766aeb2e5909f043c757f4' 
  AND token = 'oUQNs36PgdL216kOzUYXVVEUaBlM+Exm4JVjR76ae5Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00041

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}