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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'cab48f6d040a311025a06f6ccc7d0ef856c7ca4261083a8af5009c414d80e506' 
  AND token = 'AykwyC4WQUQucOOxdkQaLLUgjz5OvY9vBOJ0YAEgQtM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}