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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '954fd2baf1d67e50ac8d38a95a2dae745d71c3911bcd415220f9fab317a814d8' 
  AND token = 'UVtsAsryAaI8gUDc/VxCstJCRGapRm0ng8VhEOhwYF0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}