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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7b241e84e7a8de78f94fccdefd41bebd4151c0cd2d8407fcea12ecd42c42335d' 
  AND token = 'ECe1ggtR150TPjAwLR+rDMG4uclaZKj3MkWbMvIr0Y8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}