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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '648c7b5b6c3e420329bea45113f8f25c62efed5ccaa8c8e6db20ca378daeffb6' 
  AND token = 'dquIp15MBWKhWLLrS9cD3Gk4BET2uIvJ5FhbrofW9BY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}