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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '26d8d85ad8f018306c5d6d117029f3534dabd1bea9ef29482e035cf7cf5a9f12' 
  AND token = 'GQrLbpz4D1RWCjLtJOxaSZ3OiarKO9aA5yD0PMCJTKs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}