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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '16b4937c109e915b7f836a3adfd005f32df7c7dd3fdf47c892972e9fb3e03642' 
  AND token = 'xBtTsJv81zWBpjS29RgoYnwNFPBf7s73C3vYVIksMp8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}