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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '18e46dfb5a8024e1ea1ff400bbe196b9389b1ea8c77d448d20e50bfac5aa583e' 
  AND token = 'Zq4pO6g52TTaaYOxMCPBuWhygAH5H28vjlj181hjQpc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}