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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2f7ac12dc94eb015c1955aae9cce35e7ebfab9f9811ee393339b528897c6ce18' 
  AND token = '80tdYX1WHrhN+UeZ6LTUOdI1terWGfX+y4o3m8BhtK0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}