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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '59e1b9a48d16501cd22300c0c281100279fd6a17005d246d2776357cf83414ca' 
  AND token = '6e2UFU54BhV+2Y2Tb6b1Zm6DgY56Vg3vzblf0rDbubI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}