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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '499d53e7ab1ed4908f7bf438675b715e2d0d75c60e3542af12c5af86c69b23b0' 
  AND token = 'w7ug3DtShQ3dGycJTKgCXCCHlu0OFOHQiHcZ3CpXTKE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}