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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '19e051a56231c1e8169a1cffd3075dd40cc188dbfd9bb73703f4e94613e1f0ec' 
  AND token = 'kQR3KF+VN3a8aQslq6hwnEF3HB1/jlM6dx7ttRK4uuU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}