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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5b0449b79943f97ae45c1b47f264bb941de78ae32cf5a17b274edcc214e59735' 
  AND token = 'fNJs4y6Gas0KGg6Lwh0YGmEcUtEr9y0/hMvR+vHEhfg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}