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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'af893b5ee0bc4fcd5c71a03994025d6f5a8be146841ba86ece47bb51d1327c9b' 
  AND token = 'FNE7T9/fTHOfAvadPEaBg1xmPKpyR5jgcPF0EI/MXyE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}