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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ff1280264c003ff61d9c37603f19a78fd7ffea4f56924b2eb610a3038e5929ba' 
  AND token = '5BwmXp7nSt18zWbbXsSNHcw+qcWi7G0BR0gzsAGW6L0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}