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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd75cf98d812a0fe23d4929e585a18407fb1b9a02620a7c440948d21b8783c529' 
  AND token = 'I0EsdKFgwA3P68GrHUczDIkKV9nBuvF9y/BHt7a0zjA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}