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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9075cf971b14dd548e3955d3916b6c6967c0003115738a8949ee9c1194247b97' 
  AND token = 'XtolMTX2+vvB1RXbojbB+Rq2aBXXhOmL3WRAKV2Vhzc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}