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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4fc80df3d89fe1fb285772f9598b431ba1150cd510fb95ab92c61b7b3c59de36' 
  AND token = 'TiD3Jg7Kc4WPQ8IKymk34G1NonTtPt39FSNc3LrwwOg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}