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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '48db48fd353c2e66df4b1e5dbfe6ec8c8cea47df4b82446de87090a5067e0c54' 
  AND token = 'kzL9DCuZiKu8ARjMBC6vBE/VW3q5Is3kCf2ZaXwm2VI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}